All 6 Uses

estrange
in
War and Peace
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The infantry who had been stopped crowded near the bridge in the trampled mud and gazed with that particular feeling of ill-will, estrangement, and ridicule with which troops of different arms usually encounter one another at the clean, smart hussars who moved past them in regular order.†
Chpt 2
Prince Andrew had grown thinner, paler, and more manly-looking, but what amazed and estranged Pierre till he got used to it were his inertia and a wrinkle on his brow indicating prolonged concentration on some one thought.†
Chpt 5 *

estranged = separated or no longer emotionally close
She held out her hand to him, and with a mixed feeling of estrangement and tenderness pressed her lips to his forehead as he stooped to kiss her hand.†
Chpt 6
In his words, his tone, and especially in that calm, almost antagonistic look could be felt an estrangement from everything belonging to this world, terrible in one who is alive.†
Chpt 12
Besides a feeling of aloofness from everybody Natasha was feeling a special estrangement from the members of her own family.†
Chpt 15
Occasionally, and it was always just after they had been happiest together, they suddenly had a feeling of estrangement and hostility, which occurred most frequently during Countess Mary's pregnancies, and this was such a time.†
Chpt 15

Definitions:

(1) (estrange)
arouse hostility or indifference where there had formerly been affection or sympathy
(2) (meaning too rare to warrant focus)
Much more rarely, estrange may mean to remove from customary environment or associations.