All 4 Uses

despair
in
Unwind, by Shusterman
(Edited)

The look of despair on Andy's face is suddenly replaced by a steely resolve bordering on triumph.
p. 15.7

despair = distress (at not knowing how to improve a bad situation)
But each time a new group of kids shows up and Lev isn't among them, a sense of despair worms its way through Connor's gut.
p. 148.4 *
The thought of Lev brings with it a wave of despair.
p. 168.6
Thoughts of his parents bring up the old feelings that drove him crazy enough to become a clapper. But now he finds that sense of despair is no longer bottomless.
p. 328.8

despair = hopelessness

Definitions:

(1) (despair as in: she felt despair)
hopelessness; or distress (such as extreme worry or sadness from feeling powerless to change a bad situation)
(2) (despair as in: do not despair)
lose hope or feel distress
(3) (despair as in: she was the despair of the team)
something that causes hopelessness or great distress
(4) (meaning too rare to warrant focus)