Both Uses

loathe
in
Utopia, by Thomas More
(Auto-generated)

But they, on the other hand, wondered at the folly of the men of all other nations, who, if they are but to buy a horse of a small value, are so cautious that they will see every part of him, and take off both his saddle and all his other tackle, that there may be no secret ulcer hid under any of them, and that yet in the choice of a wife, on which depends the happiness or unhappiness of the rest of his life, a man should venture upon trust, and only see about a handsbreadth of the face, all the rest of the body being covered, under which may lie hid what may be contagious as well as loathsome.†
*

loathsome = disgusting or very bad
nor do these only serve the public, but they serve even private men, more than the slaves themselves do: for if there is anywhere a rough, hard, and sordid piece of work to be done, from which many are frightened by the labour and loathsomeness of it, if not the despair of accomplishing it, they cheerfully, and of their own accord, take that to their share;†

loathsomeness = the quality of being disgusting or very bad

Definitions:

(1) (loathe)
hate, detest, or intensely dislike

Word Confusion: Do not confuse loathe with loath which sounds very similar or the same. Loathe is a verb while loath is an adjective describing "reluctance or unwillingness to do something." Note that loathing and loathsome are forms of the verb loathe even though both word forms lack the "e". Occasionally, you will see loath spelled as loathe even in a published book, but it is rare enough that it is generally considered an error rather than a non-standard spelling.
(2) (meaning too rare to warrant focus)