Both Uses

agony
in
Faulkner's Nobel Prize Speech
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I feel that this award was not made to me as a man, but to my work—a life's work in the agony and sweat of the human spirit, not for glory and least of all for profit, but to create out of the materials of the human spirit something which did not exist before.†
*

agony = intense suffering
Because of this, the young man or woman writing today has forgotten the problems of the human heart in conflict with itself which alone can make good writing because only that is worth writing about, worth the agony and the sweat.†

Definitions:

(1) (agony)
intense feelings of suffering -- can be from mental or physical pain
(2) (meaning too rare to warrant focus)