All 3 Uses

profound
in
Atonement, by Ian McEwan
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Cecilia wondered, as she sometimes did when she met a man for the first time, if this was the one she was going to marry, and whether it was this particular moment she would remember for the rest of her life—with gratitude, or profound and particular regret.†
Chpt 1
That the word had been written by a man confessing to an image in his mind, confiding a lonely preoccupation, disgusted her profoundly.†
Chpt 1 *
He laughed politely, though he must have thought me profoundly stupid.†
Chpt 3

Definitions:

(1) (profound as in: profound idea)
deep or far-reaching in intellect or consequence
(2) (profound as in: profound sadness)
of greatest intensity or emotional depth
(3) (meaning too rare to warrant focus)