All 5 Uses

profound
in
Pudd'nhead Wilson
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A profound terror had taken possession of her.
Chpt 3 *

profound = of greatest intensity or emotional depth
The next day—that is to say, on the fourth of September—something occurred which profoundly impressed Roxana.†
Chpt 2
Tom was entirely sobered, and profoundly impressed.†
Chpt 11
This was not news, but now it was seen to have been sorrowfully prophetic, and a profound sensation quivered through the hushed courtroom when those dismal words were repeated.†
Chpt 20
He waited yet one, two, three moments, to let his pause complete and perfect its spell upon the house; then, when through the profound hush he could hear the ticking of the clock on the wall, he put out his hand and took the Indian knife by the blade and held it aloft where all could see the sinister spots upon its ivory handle; then he said, in a level and passionless voice: "Upon this haft stands the assassin's natal autograph, written in the blood of that helpless and unoffending old man who loved you and whom you all loved.†
Chpt 21

Definitions:

(1) (profound as in: profound idea)
deep or far-reaching in intellect or consequence
(2) (profound as in: profound sadness)
of greatest intensity or emotional depth
(3) (meaning too rare to warrant focus)