All 5 Uses

resignation
in
The Bridge of San Luis Rey
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At last she resigned all pretense.
Chpt 2 *

resigned = gave up
She was listening to the new tide of resignation that was rising within her.†
Chpt 2
This language was the symbol of their profound identity with one another, for just as resignation was a word insufficient to describe the spiritual change that came over the Marquesa de Montemayor on that night in the inn at Cluxambuqua, so love is inadequate to describe the tacit almost ashamed oneness of these brothers.†
Chpt 3
You must be resigned.†
Chpt 4
He tore up his findings and cast them into the waves; he gazed for an hour upon the great clouds of pearl that hang forever upon the horizon of that sea, and extracted from their beauty a resignation that he did not permit his reason to examine.†
Chpt 5

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."