All 4 Uses

antagonist
in
Profiles in Courage
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The intellect of the Puritan—of John Quincy Adams and his forebears—was, as George Frisbie Hoar has said: fit for exact ethical discussion, clear in seeing general truths, active, unresting, fond of inquiry and debate, but penetrated and restrained by a shrewd common sense......He had a tenacity of purpose, a lofty and inflexible courage, an unbending will, which never qualified or flinched before human antagonist, or before exile, torture, or death.†
Chpt 1.2

antagonist = someone who offers opposition or is hostile
For upon the heels of his election, the jealous and antagonistic Timothy Pickering (who had been dismissed as Secretary of State by his father) was selected as Adams' Senatorial colleague to fill a short-term vacancy.†
Chpt 1.2 *

antagonistic = with opposition or hostility
He ought to resign from the Senate now, said the antagonistic Gazette, instead of "holding on to the barren office ....merely to receive his per diem allowance."†
Chpt 2.5
When a Southern antagonist taunted him on the Senate floor that his vote against the Kansas-Nebraska Bill had now insured his defeat, Houstonmerely replied with a graceful smile that it was true "that I have received an earnest and gratifying assurance from my constituents that they intend to relieve me of further service here......"†
Chpt 2.5

antagonist = someone who offers opposition or is hostile

Definitions:

(1) (antagonist as in: the antagonist in the film)
someone who offers opposition or is hostile
(2) (meaning too rare to warrant focus)
Specialized Definitions of antagonist:
- literature or storytelling: the most important character who opposes the main character or protagonist
- physiology: a muscle that relaxes when another muscle contracts
- chemistry and biology: a substance that interferes with the effect of another substance