All 5 Uses

resignation
in
Long Day's Journey into Night
(Auto-generated)

All we can do is try to be resigned -- again.
Act 4 *

resigned = accepting as inevitable something undesired
MARY Her bitterness receding into a resigned helplessness.†
Act 1
There is condemnation in his face, mingled now with the beginning of an old weary, helpless resignation.†
Act 2
Then dully resigned.†
Act 2
But despite all the whiskey in him, he has not escaped, and he looks as he appeared at the close of the preceding act, a sad, defeated old man, possessed by hopeless resignation.†
Act 4

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."