All 4 Uses

profound
in
Sula
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...solitary little girls whose loneliness was so profound...
Chpt 1922 *

profound = intense
FOREWORD In the fifties, when I was a student, the embarrassment of being called a politically minded writer was so acute, the fear of critical derision for channeling one's creativity toward the state of social affairs so profound, it made me wonder: Why the panic?†
Chpt Frwd.
The vomiting of a young girl finally broke the profound silence and caused the women to talk to each other and to God.†
Chpt 1923
There, in the center of that silence was not eternity but the death of time and a loneliness so profound the word itself had no meaning.†
Chpt 1939

Definitions:

(1) (profound as in: profound idea)
deep or far-reaching in intellect or consequence
(2) (profound as in: profound sadness)
of greatest intensity or emotional depth
(3) (meaning too rare to warrant focus)