All 3 Uses

despair
in
The Masque of the Red Death
(Auto-generated)

...sudden impulses of despair or of frenzy from within.
*

despair = hopelessness
Then, summoning the wild courage of despair, a throng of the revellers at once threw themselves into the black apartment, and, seizing the mummer, whose tall figure stood erect and motionless within the shadow of the ebony clock, gasped in unutterable horror at finding the grave-cerements and corpse-like mask which they handled with so violent a rudeness, untenanted by any tangible form.†
And one by one dropped the revellers in the blood-bedewed halls of their revel, and died each in the despairing posture of his fall.†

Definitions:

(1) (despair as in: she felt despair)
hopelessness; or distress (such as extreme worry or sadness from feeling powerless to change a bad situation)
(2) (despair as in: do not despair)
lose hope or feel distress
(3) (despair as in: she was the despair of the team)
something that causes hopelessness or great distress
(4) (meaning too rare to warrant focus)