All 5 Uses

resignation
in
The Horse Whisperer
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Her footsteps as she came through the hall sounded more resigned than angry.
Chpt 4 *

resigned = like someone who had accepted something undesired as unavoidable
She would tell Gates that if he didn't reinstate Lucy Friedman she would resign.
Chpt 26 *

resign = quit her job
And Annie was by now resigned to the notion that here history was inexorably repeating.†
Chpt 2
She could feel Annie's reaction, picture the irked look on her face giving way to resignation.†
Chpt 14
The first, from Crawford Gates, said that with the greatest possible regret he must accept her resignation.†
Chpt 27

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."