All 6 Uses

resignation
in
The Unbearable Lightness of Being
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...he resigned himself with a sigh to a sea of words with no weight and no resemblance to life.
Chpt 3 *

resigned = gave up (accepting something undesired as unavoidable or the lesser of evils)
The very next day he resigned from the clinic,
Chpt 5 *

resigned = quit (a job)
Perhaps you can find a way to keep me on even without a statement, said Tomas, trying to hint that a threat by all his colleagues to resign upon his dismissal would suffice.†
Chpt 5
But his colleagues never dreamed of threatening to resign, and so before long (the chief surgeon shook his hand even more energetically than the previous timeit was black and blue for days), he was forced to leave the hospital.†
Chpt 5
The official with whom Tomas negotiated his resignation knew him by name and reputation and tried to talk him into staying on.†
Chpt 5
He was in the situation of a chess player who cannot avoid checkmate and is forced to resign.†
Chpt 5

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."