All 7 Uses

resignation
in
Madame Bovary
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And Charles, his head in his hands, went on in a broken voice, and with the resigned accent of infinite sorrow—.
Chpt 3.11 *

resigned = having accepted something undesired as unavoidable
Still she was resigned.†
Chpt 1.8
Then, pride, and joy of being able to say to herself, "I am virtuous," and to look at herself in the glass taking resigned poses, consoled her a little for the sacrifice she believed she was making.†
Chpt 2.5
She had made up her mind to resignation, to universal indulgence.†
Chpt 2.14
"Well, they were wrong," said Bournisien, resigned to anything.†
Chpt 2.14
"I haven't got them," replied Rodolphe, with that perfect calm with which resigned rage covers itself as with a shield.†
Chpt 3.8
Chapter Nine There is always after the death of anyone a kind of stupefaction; so difficult is it to grasp this advent of nothingness and to resign ourselves to believe in it.†
Chpt 3.9

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."