All 3 Uses of

resignation
in
Beloved, by Toni Morrison

...resigned to life without aunts, cousins, children.
Part 2 *

resigned = Having accepted something undesired as unavoidable

That she lived with 124 in helpless, apologetic resignation because she had no choice; that minus husband, sons, mother-in-law, she and her slow-witted daughter had to live there all alone making do.†
Part 1

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
meaning too rare to warrant focus:

To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."