All 5 Uses

resignation
in
Harry Potter (#3) and the Prisoner of Azkaban
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Resigned to the fact that he would be the only third year staying behind again,
Chpt 10 *

resigned = having accepted (an unpleasant situation)
And he said you'd resigned.
Chpt 22 *

resigned = quit (his job)
Resigned firs' thing this mornin'.†
Chpt 22
But if he's resigned —†
Chpt 22
The whole of Harry's Defense Against the Dark Arts class was miserable about his resignation.†
Chpt 22

Definitions:

(1) (resignation as in: submitted her resignation)
to quit -- especially a job or position; or a document expressing such an act
(2) (resignation as in: accepted it with resignation)
acceptance of something undesired as unavoidable or the lesser of evils
(3) (meaning too rare to warrant focus)
To resign can also more specifically mean to surrender or give up as in "I was clearly going to lose the chess game, so I resigned;" or "She resigned all pretense."