All 6 Uses

profound
in
Childhood's End
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The mild alcoholic fog prevented any profound analysis of what had happened,
Chpt 9 *

profound = deep or far-reaching in intellect or insight
...such natural catastrophes as earthquakes or floods, which might have a profound effect on large numbers of people...
Chpt 15 *

profound = very intense
Profounder things had also passed.†
Chpt 6
Though it had always been obvious to any rational mind that all the world's religious writings could not be true, the shock was nevertheless profound.†
Chpt 6
George eyed the device with profound distrust.†
Chpt 8
Yet sometimes there were suggestions of profound, even disturbing truths: REMEMBER MAN IS NOT ALONE — NEAR MAN IS COUNTRY OF OTHERS.†
Chpt 8

Definitions:

(1) (profound as in: profound idea)
deep or far-reaching in intellect or consequence
(2) (profound as in: profound sadness)
of greatest intensity or emotional depth
(3) (meaning too rare to warrant focus)