All 6 Uses

sovereign
in
Antony and Cleopatra
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Sovereign of Egypt, hail!
Scene 1.5 *

sovereign = supreme ruler
Look here, and, at thy sovereign leisure, read The garboils she awak'd;at the last, best.†
Scene 1.3
O sovereign mistress of true melancholy, The poisonous damp of night disponge upon me, That life, a very rebel to my will, May hang no longer on me: throw my heart Against the flint and hardness of my fault; Which, being dried with grief, will break to powder, And finish all foul thoughts.†
Scene 4.9
She is dead too, our sovereign.†
Scene 4.15
—But we do lance Diseases in our bodies: I must perforce Have shown to thee such a declining day Or look on thine; we could not stall together In the whole world: but yet let me lament, With tears as sovereign as the blood of hearts, That thou, my brother, my competitor In top of all design, my mate in empire, Friend and companion in the front of war, The arm of mine own body, and the heart Where mine his thoughts did kindle,—that our stars, Unreconciliable, should divide Our equalness to this.†
Scene 5.1
Most sovereign creature,— CLEOPATRA.†
Scene 5.2

Definitions:

(1) (sovereign)
a supreme ruler; or describing a political body as self-governing
(2) (meaning too rare to warrant focus)
a British coin used until 1914; an adjective describing something as powerfully effective