All 5 Uses

loathe
in
Romeo and Juliet
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Prodigious birth of love it is to me,
That I must love a loathed enemy.
p. 61.7

loathed = intensely disliked
The sweetest honey
Is loathsome in his own deliciousness
And in the taste confounds the appetite.
p. 111.1

loathsome = bad
It is, it is. Hie hence, begone, away!
It is the lark that sings so out of tune,
Straining harsh discords and unpleasing sharps.
Some say the lark makes sweet division.
This doth not so, for she divideth us.
Some say the lark and loathed toad changed eyes.
O, now I would they had changed voices too,
Since arm from arm that voice doth us affray,
Hunting thee hence with hunt's-up to the day.
O, now begone. More light and light it grows.†
p. 157.9

loathed = detested or intensely disliked
with loathsome smells
p. 193.6 *

loathsome = disgusting
There is thy gold, worse poison to men's souls,
Doing more murders in this loathsome world
Than these poor compounds that thou mayst not sell.
p. 217.2

Definitions:

(1) (loathe)
hate, detest, or intensely dislike

Word Confusion: Do not confuse loathe with loath which sounds very similar or the same. Loathe is a verb while loath is an adjective describing "reluctance or unwillingness to do something." Note that loathing and loathsome are forms of the verb loathe even though both word forms lack the "e". Occasionally, you will see loath spelled as loathe even in a published book, but it is rare enough that it is generally considered an error rather than a non-standard spelling.
(2) (meaning too rare to warrant focus)