All 4 Uses

despair
in
1984, by Orwell
(Edited)

It was a great formidable cry of anger and despair, a deep, loud 'Oh-o-o-o-oh!' that went humming on like the reverberation of a bell.
p. 69.9

despair = desperation
But at this moment the general despair broke down into a multitude of individual quarrels.
p. 70.2
There were times when the fact of impending death seemed as palpable as the bed they lay on, and they would cling together with a sort of despairing sensuality, like a damned soul grasping at his last morsel of pleasure when the clock is within five minutes of striking.
p. 151.5 *

despairing = hopeless
He heard also a deep groan of despair.
p. 286.2

despair = desperation

Definitions:

(1) (despair as in: she felt despair)
hopelessness; or distress (such as extreme worry or sadness from feeling powerless to change a bad situation)
(2) (despair as in: do not despair)
lose hope or feel distress
(3) (despair as in: she was the despair of the team)
something that causes hopelessness or great distress
(4) (meaning too rare to warrant focus)