All 6 Uses

notwithstanding
in
Frankenstein - 1831 version
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I was undisturbed by thoughts which during the preceding year had pressed upon me, notwithstanding my endeavours to throw them off, with an invincible burden.†
p. 71.8 *
No one would believe it at first; and even now Elizabeth will not be convinced, notwithstanding all the evidence.†
p. 80.4
For my own part, I do not hesitate to say that, notwithstanding all the evidence produced against her, I believe and rely on her perfect innocence.†
p. 86.5
I am not one of your enemies, I believed you guiltless, notwithstanding every evidence, until I heard that you had yourself declared your guilt.†
p. 88.2
As Mr. Kirwin said this, notwithstanding the agitation I endured on this retrospect of my sufferings, I also felt considerable surprise at the knowledge he seemed to possess concerning me.†
p. 184.2
I did not weep, but I knelt down and with a full heart thanked my guiding spirit for conducting me in safety to the place where I hoped, notwithstanding my adversary's gibe, to meet and grapple with him.†
p. 209.6

Definitions:

(1) (notwithstanding)
used to show that something remains true even though something else seems to go against it

Most commonly, you can substitute "in spite of" for notwithstanding. But see the first exemplary sample sentences for other common word substitutions.
(2) (meaning too rare to warrant focus)