The doctor weighed the efficacy of each treatment against potential side-effects.
They held hearings to investigate concerns about the safety and efficacy of the vaccine.
There was relief all around, but soon the thread had been overtaken by a multi-participant debate about the efficacy of that war, U.S. foreign policy in general, whether or not we won in Vietnam or Grenada or even WWI, and the ability of the Afghans to self-govern, and the opium trade financing the insurgents, and the possibility of legalization of any and all illicit drugs in America and Europe.
Dave Eggers -- The Circle
But questions about the painlessness and efficacy of lethal injection were emerging.
Bryan Stevenson -- Just Mercy
Yet with Mrs. Brown constantly lecturing me about the efficacy of leather on flesh and interfering when the fights did break out, I needed some way to control the kids instantly and silently.
Pat Conroy -- The Water is Wide
It soon proved its efficacy, and redeemed the leech’s pledge.
Nathaniel Hawthorne -- The Scarlet Letter
I wonder who first discovered the efficacy of poetry in driving away love!
Jane Austen -- Pride and Prejudice
I have confidence in the remedy I propose, and only ask you to permit me to assure you of its efficacy.
Alexandre Dumas -- The Count of Monte Cristo
He gave the facts with flat efficacy.
Dan Brown -- Angels & Demons
That’s the kind of fatalism and pessimism typical of a repressive feudal system, where peasants have no reason to believe in the efficacy of their own work.
Malcolm Gladwell -- Outliers
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I have never believed in the efficacy of idealists-have you?and this is no age for impractical idealism.
Ayn Rand -- Atlas Shrugged
The snarling of his dogs was losing its efficacy.
Jack London -- White Fang
"Don’t do it!" said Mr. Crunches looking about, as if he rather expected to see the loaf disappear under the efficacy of his wife’s petitions.
Charles Dickens -- A Tale of Two Cities
Now, I say, is the time when the virtue that is in thee is ripe, and endowed with efficacy to work the good that is looked for from thee.
Miguel de Cervantes -- Don Quixote
It is worthy of remark, as a curious physical instance of the efficacy of a sudden surprise in counteracting the effects of extreme fear, that her voice had quite recovered all its official asperity.
Charles Dickens -- Oliver Twist
The evil side of my nature, to which I had now transferred the stamping efficacy, was less robust and less developed than the good which I had just deposed.
Robert Louis Stevenson -- Dr. Jekyll and Mr. Hyde
"Sir,’ said he, in a great surprise, ’I do not mean that you should separate, but marry them, by a written contract, signed by both man and woman, and by all the witnesses present, which all the European laws decree to be of sufficient efficacy."
Daniel Defoe -- Robinson Crusoe
The adjutants general were there because they always accompanied the Emperor, and lastly and chiefly Pfuel was there because he had drawn up the plan of campaign against Napoleon and, having induced Alexander to believe in the efficacy of that plan, was directing the whole business of the war.
Leo Tolstoy -- War and Peace
This apprehension had not been without efficacy in determining me to summary means.
Herman Melville -- Bartleby, the Scrivener: a Story of Wall Street
If there resided any efficacy in devotion at all, surely it lay in a visit to this great shrine.
Thornton Wilder -- The Bridge of San Luis Rey
The scout listened to the tremulous voice in which the veteran delivered these words, and shook his head slowly when they were ended, as one who doubted their efficacy.
James Fenimore Cooper -- The Last of the Mohicans
With evening quickly approaching, an intense discussion began regarding the efficacy of immediate pursuit or holding off until daybreak.
William P. Young -- The Shack
Hivert openly cast some doubt on the efficacy of it.
Gustave Flaubert -- Madame Bovary
It was as potent, and perhaps endowed with the same kind of efficacy, as a galvanic ring!
Nathaniel Hawthorne -- The House of the Seven Gables
The very mysteriousness of such a cure made her the more confident of its efficacy.
Edith Wharton -- The Age of Innocence
Almighty Adonai, Arathron, Ashai, Elohim, Elohi, Elion, Asher Eheieh, Shaddai …. be my aid, so that this blood may have power and efficacy in all wherein I shall wish, and in all that I shall demand.
Dan Brown -- The Lost Symbol
The reader will remember the great epidemic of croup which ravaged the river districts of the Seine in Paris thirty-five years ago, and of which science took advantage to make experiments on a grand scale as to the efficacy of inhalations of alum, so beneficially replaced at the present day by the external tincture of iodine.
Victor Hugo -- Les Miserables
No one doubted that the sanitary rigor of Dr. Juvenal Urbino, more than the efficacy of his pronouncements, had made the miracle possible.
Gabriel Garcia Marquez -- Love in the Time of Cholera
Elizabeth had nothing to propose of deeper efficacy.
Jane Austen -- Persuasion
She had already satisfied herself that he thought Harriet a beautiful girl, which she trusted, with such frequent meetings at Hartfield, was foundation enough on his side; and on Harriet’s there could be little doubt that the idea of being preferred by him would have all the usual weight and efficacy.
Jane Austen -- Emma
Rather, her manner of naming tells us a great deal about the society that would lead a man, Pilate’s father, to have absolute faith in the efficacy of a book he cannot read, so much so that he is guided by a principle of blind selection.
Thomas C. Foster -- How to Read Literature Like a Professor
The pen and all its relations being awkward tools in Henchard’s hands he had affixed the seals without an impression, it never occurring to him that the efficacy of such a fastening depended on this.
Thomas Hardy -- The Mayor of Casterbridge
Moralists had, as a rule, regarded it as a mode of warning, had claimed for it a certain ethical efficacy in the formation of character, had praised it as something that taught us what to follow and showed us what to avoid.
Oscar Wilde -- The Picture of Dorian Gray
The good woman no sooner felt the gold within her palm, than her temper began (such is the efficacy of that panacea) to be mollified.
Henry Fielding -- Tom Jones
She gave him the information and then told him, in effect, "Surely you are collecting these leaves in order to better understand their power and improve their efficacy."
Tracy Kidder -- Mountains Beyond Mountains
This total failure of the coal-hole discipline shook Silas’s belief in the efficacy of punishment.
George Eliot -- Silas Marner
Behold! there is a medicine, potent, as a wise physician has assured me, and almost divine in its efficacy.
Nathaniel Hawthorne -- Rappaccini’s Daughter
It’s true that the American public is unduly impressed by such notions — they favour cures that can be had by pulling a lever or pressing a button — but Simon has no belief in their efficacy.
Margaret Atwood -- Alias Grace
These two cadets are concerned about the efficacy of allowing a senior private to address the incoming freshmen.
Pat Conroy -- The Lords of Discipline
The wonder is that characteristic efficacy to touch and inspire deep creative centers dwells in the smallest nursery fairy tale—as the flavor of the ocean is contained in a droplet or the whole mystery of life within the egg of a flea.
Joseph Campbell -- The Hero With a Thousand Faces
Then their sister, with much augmented confidence in the efficacy of the sacrament, poured forth from the bottom of her heart the thanksgiving that follows, uttering it boldly and triumphantly in the stopt-diapason note which her voice acquired when her heart was in her speech, and which will never be forgotten by those who knew her.
Thomas Hardy -- Tess of the d’Urbervilles
Lydgate, inclined to be sarcastic on the superstitious faith of the people in the efficacy of "the bill," while nobody cared about the low state of pathology, sometimes assailed Will with troublesome questions.
George Eliot -- Middlemarch
To the blanc moon Her office they prescribed; to the other five Their planetary motions, and aspects, In sextile, square, and trine, and opposite, Of noxious efficacy, and when to join In synod unbenign; and taught the fixed Their influence malignant when to shower, Which of them rising with the sun, or falling, Should prove tempestuous: To the winds they set Their corners, when with bluster to confound Sea, air, and shore; the thunder when to roll With terrour through the dark aereal…
John Milton -- Paradise Lost
She knew it was not by explanations and counter-charges that she could ever hope to recover her lost standing; but even had she felt the least trust in their efficacy, she would still have been held back by the feeling which had kept her from defending herself to Gerty Farish—a feeling that was half pride and half humiliation.
Edith Wharton -- The House of Mirth
…his 1d bazaar at 42 George’s street, south, the latter at his 6 1/2d shop and world’s fancy fair and waxwork exhibition at 30 Henry street, admission 2d, children 1d: and the infinite possibilities hitherto unexploited of the modern art of advertisement if condensed in triliteral monoideal symbols, vertically of maximum visibility (divined), horizontally of maximum legibility (deciphered) and of magnetising efficacy to arrest involuntary attention, to interest, to convince, to decide.
James Joyce -- Ulysses
The great problem of the shifting relation between passion and duty is clear to no man who is capable of apprehending it; the question whether the moment has come in which a man has fallen below the possibility of a renunciation that will carry any efficacy, and must accept the sway of a passion against which he had struggled as a trespass, is one for which we have no master-key that will fit all cases.
George Eliot -- The Mill on the Floss
To any inquiries, the consulate was to comment only that during the next month numerous representatives of the American government and American industry would be flying into the colony at various undetermined times, and security as well as the efficacy of accommodations warranted the lease.
Robert Ludlum -- The Bourne Supremacy
…a book in her hand, which she was unable to read, or in lying, weary and languid, on a sofa, did not speak much in favour of her amendment; and when, at last, she went early to bed, more and more indisposed, Colonel Brandon was only astonished at her sister’s composure, who, though attending and nursing her the whole day, against Marianne’s inclination, and forcing proper medicines on her at night, trusted, like Marianne, to the certainty and efficacy of sleep, and felt no real alarm.
Jane Austen -- Sense and Sensibility
We know its efficacy in trouble and illness.
Zane Grey -- The Heritage of the Desert
To the efficacy and permanency of your Union, a government for the whole is indispensable.
George Washington -- Washington’s Farewell Address