Billee’s one fault was his excessive good nature, while Joe was the very opposite, sour and introspective, with a perpetual snarl and a malignant eye.
On the next day Koona went, and but five of them remained: Joe, too far gone to be malignant; Pike, crippled and limping, only half conscious and not conscious enough longer to malinger; Sol-leks, the one-eyed, still faithful to the toil of trace and trail, and mournful in that he had so little strength with which to pull; Teek, who had not travelled so far that winter and who was now beaten more than the others because he was fresher; and Buck, still at the head of the team, but no…
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Gey and his wife, Margaret, had spent the last three decades working to grow malignant cells outside the body, hoping to use them to find cancer’s cause and cure.
Rebecca Skloot -- The Immortal Life of Henrietta Lacks
He hit it [the shark] without hope but with resolution and complete malignancy.