His father, who had died young, had filled a small diplomatic post, and it had been intended that the son should follow the same career; but an insatiable taste for letters had thrown the young man into journalism, then into authorship (apparently unsuccessful), and at length—after other experiments and vicissitudes which he spared his listener—into tutoring English youths in Switzerland.
There are no more uses of "vicissitudes" in the book.
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the project was subject to the usual vicissitudes of exploratory research
Jack stood there, streaming with sweat, streaked with brown earth, stained by all the vicissitudes of a day’s hunting.