He had been coming and going, for the past year, so comfortably and irresponsibly, that he had a certain sense of being wronged by finding himself reminded that he must now limit his horizon to the front parlour, which was Catherine’s particular province.
There are no more uses of "irresponsible" in the book.
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After much passing around of money Cousin Joshua was moved across the tracks and placed in state accommodations for the irresponsible, where he remained for the rest of his days.
Harper Lee -- Go Set a Watchman
"The fact of the matter is, we’ve been irresponsible," Marybeth continues.