Even at the age of twentyseven Austin Sloper had made his mark sufficiently to mitigate the anomaly of his having been chosen among a dozen suitors by a young woman of high fashion, who had ten thousand dollars of income and the most charming eyes in the island of Manhattan.
There are no more uses of "anomaly" in the book.
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We consider the accident an anomaly — not a reason to change standard procedures.
They rate a nuclear event from 1 (an anomaly) to 7 (a major accident).