In this case, however, they have established a very serious case against the son of the murdered man.
Dr. Roylott then abandoned his attempts to establish himself in practice in London and took us to live with him in the old ancestral house at Stoke Moran.
The last squire dragged out his existence there, living the horrible life of an aristocratic pauper; but his only son, my stepfather, seeing that he must adapt himself to the new conditions, obtained an advance from a relative, which enabled him to take a medical degree and went out to Calcutta, where, by his professional skill and his force of character, he established a large practice.
"Remember, Watson that though we have so homely a thing as a goose at one end of this chain, we have at the other a man who will certainly get seven years’ penal servitude unless we can establish his innocence.
There are no more uses of "establish" in the book.