Counsel for the defence rose and said: "Your honor, in our remarks at the opening of this trial, we foreshadowed our purpose to prove that our client did this fearful deed while under the influence of a blind and irresponsible delirium produced by drink.
There are no more uses of "irresponsible" in the book.
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After much passing around of money Cousin Joshua was moved across the tracks and placed in state accommodations for the irresponsible, where he remained for the rest of his days.
Harper Lee -- Go Set a Watchman
"The fact of the matter is, we’ve been irresponsible," Marybeth continues.