It would distress me more than I can tell you, dear Gwendolen, if it caused you any mental or physical anguish, but I feel bound to point out that since Ernest proposed to you he clearly has changed his mind.
There are no more uses of "anguish" in the play.
Show samples from other sources
I felt unbearable anguish when my 4-year-old child died from brain cancer.
Her guilt led to anguish until she committed her life to good.