These were the circumstances and the hopes which gradually brought their alleviation to Sir Thomas, deadening his sense of what was lost, and in part reconciling him to himself; though the anguish arising from the conviction of his own errors in the education of his daughters was never to be entirely done away.
There are no more uses of "anguish" in the book.
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I felt unbearable anguish when my 4-year-old child died from brain cancer.
Her guilt led to anguish until she committed her life to good.