…and reduce that empire to a province, to be governed by a viceroy from hence, and to destroy and put to death, not only all the Big-endian exiles, but likewise all the people of that empire who would not immediately forsake the Big-endian heresy, he, the said Flestrin, like a false traitor against his most auspicious, serene, imperial majesty, did petition to be excused from the said service, upon pretence of unwillingness to force the consciences, or destroy the liberties and lives of…
There are no more uses of "heresy" in the book.
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It is a hardline form of Sunni Islam that condemns all other strains as heresy.
Before the separation of Church and State, an accusation of heresy could be treated as treason.