He had never before been so much struck with the fact that this unfortunate bay was a roarer to a degree which required the roundest word for perdition to give you any idea of it.
The evidence of his cleverness was of the higher intuitive order, lying in his lady-patients’ immovable conviction, and was unassailable by any objection except that their intuitions were opposed by others equally strong; each lady who saw medical truth in Wrench and "the strengthening treatment" regarding Toller and "the lowering system" as medical perdition.
Rosamond had that morning entreated him to urge this step on Lydgate; and it seemed to him as if he were beholding in a magic panorama a future where he himself was sliding into that pleasureless yielding to the small solicitations of circumstance, which is a commoner history of perdition than any single momentous bargain.
The current carried even Mr. Horrock with it, but this committal of himself to an opinion fell from him with so little sacrifice of his neutral expression, that the bid might not have been detected as his but for the friendly oaths of Mr. Bambridge, who wanted to know what Horrock would do with blasted stuff only fit for haberdashers given over to that state of perdition which the horse-dealer so cordially recognized in the majority of earthly existences.
There are no more uses of "perdition" in the book.
Show samples from other sources
Paul envisaged the whole of mankind, both Jew and Gentile, as being in this fatal state of perdition and as needing a common savior, who is Jesus.
Dictionary of the History of Ideas -- http://etext.lib.virginia.edu/cgi-local/DHI/dhi.cgi?id=dv1-50(retrieved 05/20/06)
Then I considered the fact that they both simply might be crazy, or outcast like Paolo and Francesca, caught up in some weird, shared perdition.