Looking at the mother, you might hope that the daughter would become like her, which is a prospective advantage equal to a dowry—the mother too often standing behind the daughter like a malignant prophecy—"Such as I am, she will shortly be."
With the reasons which kept Bulstrode in dread of Raffles there flashed the thought that the dread might have something to do with his munificence towards his medical man; and though he resisted the suggestion that it had been consciously accepted in any way as a bribe, he had a foreboding that this complication of things might be of malignant effect on Lydgate’s reputation.
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Gey and his wife, Margaret, had spent the last three decades working to grow malignant cells outside the body, hoping to use them to find cancer’s cause and cure.
Rebecca Skloot -- The Immortal Life of Henrietta Lacks
He hit it [the shark] without hope but with resolution and complete malignancy.