Mr. Wrench was a small, neat, bilious man, with a well-dressed wig: he had a laborious practice, an irascible temper, a lymphatic wife and seven children; and he was already rather late before setting out on a four-miles drive to meet Dr. Minchin on the other side of Tipton, the decease of Hicks, a rural practitioner, having increased Middlemarch practice in that direction.
Unlike our irascible friend Wrench, he had the easiest way in the world of taking things which might be supposed to annoy him, being a well-bred, quietly facetious man, who kept a good house, was very fond of a little sporting when he could get it, very friendly with Mr. Hawley, and hostile to Mr. Bulstrode.
There are no more uses of "irascible" in the book.
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She has an irascible nature at the best of times, but be especially careful to avoid her early in the morning.