Let this pernicious hour stand aye accursed in the calendar!
This avarice Sticks deeper; grows with more pernicious root Than summer-seeming lust; and it hath been The sword of our slain kings: yet do not fear; Scotland hath foysons to fill up your will, Of your mere own: all these are portable, With other graces weigh’d.
There are no more uses of "pernicious" in the play.
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By the 21st century, it had evolved into a pernicious lack of employment.