There were men, too, of a sturdier texture of mind than his, and endowed with a far greater share of shrewd, hard iron, or granite understanding; which, duly mingled with a fair proportion of doctrinal ingredient, constitutes a highly respectable, efficacious, and unamiable variety of the clerical species.
There are no more uses of "doctrine" in the book.
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She challenges accepted doctrine.
The Monroe Doctrine helped to limit European influence in South America.