For upwards of twenty years before this epoch, the independent position of the Collector had kept the Salem Custom-House out of the whirlpool of political vicissitude, which makes the tenure of office generally so fragile.
So great a vicissitude in his life could not at once be received as real.
There are no more uses of "vicissitudes" in the book.
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the project was subject to the usual vicissitudes of exploratory research
Jack stood there, streaming with sweat, streaked with brown earth, stained by all the vicissitudes of a day’s hunting.