There were men, too, of a sturdier texture of mind than his, and endowed with a far greater share of shrewd, hard iron, or granite understanding; which, duly mingled with a fair proportion of doctrinal ingredient, constitutes a highly respectable, efficacious, and unamiable variety of the clerical species.
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The drug is safe and efficacious.
He would weep for hours together, and I verily believe that to the very end this spoiled child of life thought his weak tears in some way efficacious.