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Multiple Meanings

Her father had a way of undermining his sister’s lectures on the innate superiority of any given Finch: he always told his daughter the rest of it, quietly and solemnly, but Jean Louise sometimes thought she detected an unmistakably profane glint in Atticus Finch’s eyes, or was it merely the light hitting his glasses?
Harper Lee  --  Go Set a Watchman
grossly irreverent toward what is held to be sacred

Much more rarely profane may mean that something is not sacred or concerned with religion; or that it is not holy because it is unconsecrated, impure or defiled.
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